These are really good tires. I ride year 'round in mostly hot/humid weather and also in the winter down south. I travel for work and bring my bike lots of time especially to NYC for 60, 70, or 80 mile rides. I run tubeless and use Orange Seal regular and Ive had great results. Yeah, punctures happen especially in urban riding (Jersey City, NYC, etc.) but if you keep your sealant level up, inside of tires clean, and don't over pressure, these tires have wonderful longevity. Also, they corner nicely and generally ride well. I have no need to explore tubeless ready tires any further after the GP5000 TR. If you are a nut about maintenance (which you should be) and keep track of your tires and mileage these should be good for 4000 miles before you get to the bottom of the wear indicator although I wish I could get any tire to the bottom of the wear indicator. +1 for the GP5000 TR.
After trying multiple tires (I ride about 18,000 miles/year), I've settled on the Conti GP5000 for its smooth ride, low rolling resistance and relatively good puncture proof tires. It's a bit pricier, but worth it overall given that I get about 6000 miles out of each tire. They're a bit difficult to put on, but fortunately I've not had to take them off regularly for any reason (especially punctures). They're grippy and you feel confident after a good bit of usage.
I use these everyday. They mount up easy with my old hands only. Inflate easily and hold air like no other tire I've owned. They roll and corner very fast. I had another set from a major tire company and when I mounted and rode with these, I immediately felt I could corner better and roll faster. They were just a tad harsher which I think maybe because once mounted they were exactly 32 mm as the other set measured 34 even though they were both 32 mm tires.
I love these tires. I used to get constant flats biking around Chicago from all the broken glass etc in the streets, especially in the winter and spring when there is no street cleaning. Since switching to gatorskins I rarely get flats, and if I do it's a reminder that maybe it's about time to switch out my old, worn pair. Hard for me to say how many miles I get off them, since I commute all year, but a pair usually lasts me a year or so. Definitely worth it for the peace of mind.