After trying multiple tires (I ride about 18,000 miles/year), I�ve settled on the Conti GP5000 for its smooth ride, low rolling resistance and relatively good puncture proof tires. It�s a bit pricier, but worth it overall given that I get about 6000 miles out of each tire. They�re a bit difficult to put on, but fortunately I�ve not had to take them off regularly for any reason (especially punctures). They�re grippy and you feel confident after a good bit of usage.
I use these everyday. They mount up easy with my old hands only. Inflate easily and hold air like no other tire I've owned. They roll and corner very fast. I had another set from a major tire company and when I mounted and rode with these, I immediately felt I could corner better and roll faster. They were just a tad harsher which I think maybe because once mounted they were exactly 32 mm as the other set measured 34 even though they were both 32 mm tires.
I love these tires. I used to get constant flats biking around Chicago from all the broken glass etc in the streets, especially in the winter and spring when there is no street cleaning. Since switching to gatorskins I rarely get flats, and if I do it's a reminder that maybe it's about time to switch out my old, worn pair. Hard for me to say how many miles I get off them, since I commute all year, but a pair usually lasts me a year or so. Definitely worth it for the peace of mind.
I recently bought 4 Continental Grand Prix 5000 tires with 6 Pirelli P Zero TPU tubes and I wish I made the switch sooner. Put them on your bike - I'm sure you'll be impressed.
I've been riding since the 1970s and got into cycle racing in 2005 in the Salt Lake City area. (We left Utah because of the shutdowns, even though I love riding up the mountains)
These tires have excellent grip (much more than other tires I've run) and the TPU tubes make riding on the rough roads in the Safford Arizona area noticeably more comfortable.
I think this is the single best performance upgrade I've made in 20 years!